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Dupont1992_Ca_dpt_protein_phospho

ABSTRACT: Model reproduces Fig 4 of the paper. For fraction of phosphorylated protein, W_star, the model reproduces panel b in the same figure. Model successfully tested on MathSBML and Jarnac. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information. In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not. To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.

SUBMITTER: Harish Dharuri  

PROVIDER: BIOMD0000000113 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Dataset's files

Source:
Action DRS
BIOMD0000000113?filename=BIOMD0000000113-biopax2.owl Owl
BIOMD0000000113?filename=BIOMD0000000113-biopax3.owl Owl
BIOMD0000000113?filename=BIOMD0000000113-matlab.m Other
BIOMD0000000113?filename=BIOMD0000000113.m Other
BIOMD0000000113?filename=BIOMD0000000113.ode Other
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Publications

Protein phosphorylation driven by intracellular calcium oscillations: a kinetic analysis.

Dupont G G   Goldbeter A A  

Biophysical chemistry 19920401 3

Given the ubiquitous nature of signal-induced Ca2+ oscillations, the question arises as to how cellular responses are affected by repetitive Ca2+ spikes. Among these responses, we focus on those involving protein phosphorylation. We examine, by numerical simulations of a theoretical model, the situation where a protein is phosphorylated by a Ca(2+)-activated kinase and dephosphorylated by a phosphatase. This reversible phosphorylation system is coupled to a mechanism generating cytosolic Ca2+ os  ...[more]

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