Dutta-Roy2015 - Opening of the multiple AMPA receptor conductance states
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ABSTRACT:
Dutta-Roy2015 - Opening of the multiple AMPA
receptor conductance states
This model is described in the article:
Ligand-dependent opening of
the multiple AMPA receptor conductance States: a concerted
model.
Dutta-Roy R, Rosenmund C, Edelstein
SJ, Le Novère N.
PLoS ONE 2015; 10(1): e0116616
Abstract:
Modulation of the properties of AMPA receptors at the
post-synaptic membrane is one of the main suggested mechanisms
underlying fast synaptic transmission in the central nervous
system of vertebrates. Electrophysiological recordings of
single channels stimulated with agonists showed that both
recombinant and native AMPA receptors visit multiple
conductance states in an agonist concentration dependent
manner. We propose an allosteric model of the multiple
conductance states based on concerted conformational
transitions of the four subunits, as an iris diaphragm. Our
model predicts that the thermodynamic behaviour of the
conductance states upon full and partial agonist stimulations
can be described with increased affinity of receptors as they
progress to higher conductance states. The model also predicts
the existence of AMPA receptors in non-liganded conductive
substates. However, the probability of spontaneous openings
decreases with increasing conductances. Finally, we predict
that the large conductance states are stabilized within the
rise phase of a whole-cell EPSC in glutamatergic hippocampal
neurons. Our model provides a mechanistic link between ligand
concentration and conductance states that can explain
thermodynamic and kinetic features of AMPA receptor gating.
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SUBMITTER: Nicolas Le Novère
PROVIDER: BIOMD0000000569 | BioModels | 2024-09-02
REPOSITORIES: BioModels
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