Araujo2016 - Positive feedback in Cdk1 signalling keeps mitotic duration short and constant

ABSTRACT: Araujo2016 - Positive feedback in Cdk1 signalling keeps mitotic duration short and constant This model is described in the article: Positive Feedback Keeps Duration of Mitosis Temporally Insulated from Upstream Cell-Cycle Events. Araujo AR, Gelens L, Sheriff RS, Santos SD. Mol. Cell 2016 Oct; 64(2): 362-375 Abstract: Cell division is characterized by a sequence of events by which a cell gives rise to two daughter cells. Quantitative measurements of cell-cycle dynamics in single cells showed that despite variability in G1-, S-, and G2 phases, duration of mitosis is short and remarkably constant. Surprisingly, there is no correlation between cell-cycle length and mitotic duration, suggesting that mitosis is temporally insulated from variability in earlier cell-cycle phases. By combining live cell imaging and computational modeling, we showed that positive feedback is the molecular mechanism underlying the temporal insulation of mitosis. Perturbing positive feedback gave rise to a sluggish, variable entry and progression through mitosis and uncoupled duration of mitosis from variability in cell cycle length. We show that positive feedback is important to keep mitosis short, constant, and temporally insulated and anticipate it might be a commonly used regulatory strategy to create modularity in other biological systems. This model is hosted on BioModels Database and identified by: BIOMD0000000657. To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Rahuman S Malik-Sheriff  

PROVIDER: BIOMD0000000657 | BioModels | 2024-09-02

REPOSITORIES: BioModels