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Reppas2015 - tumor control via alternating immunostimulating and immunosuppressive phases

ABSTRACT: The paper describes a model of tumor control via alternating immunostimulating and immunosuppressive phases. Created by COPASI 4.25 (Build 207) This model is described in the article: In silico tumor control induced via alternating immunostimulating and immunosuppressive phases AI Reppas, JCL Alfonso, and H Hatzikirou Virulence 7:2, 174--186 Abstract: Despite recent advances in the field of Oncoimmunology, the success potential of immunomodulatory therapies against cancer remains to be elucidated. One of the reasons is the lack of understanding on the complex interplay between tumor growth dynamics and the associated immune system responses. Toward this goal, we consider a mathematical model of vascularized tumor growth and the corresponding effector cell recruitment dynamics. Bifurcation analysis allows for the exploration of model’s dynamic behavior and the determination of these parameter regimes that result in immune-mediated tumor control. In this work, we focus on a particular tumor evasion regime that involves tumor and effector cell concentration oscillations of slowly increasing and decreasing amplitude, respectively. Considering a temporal multiscale analysis, we derive an analytically tractable mapping of model solutions onto a weakly negatively damped harmonic oscillator. Based on our analysis, we propose a theory-driven intervention strategy involving immunostimulating and immunosuppressive phases to induce long-term tumor control. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Jinghao Men

PROVIDER: BIOMD0000000749 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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			Action	DRS
	BIOMD0000000749?filename=Reppas2015-biopax2.owl	Owl
	BIOMD0000000749?filename=Reppas2015-biopax3.owl	Owl
	BIOMD0000000749?filename=Reppas2015-matlab.m	Other
	BIOMD0000000749?filename=Reppas2015-octave.m	Other
	BIOMD0000000749?filename=Reppas2015.cps	Other

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In silico tumor control induced via alternating immunostimulating and immunosuppressive phases.

Reppas A I AI Alfonso J C L JC Hatzikirou H H

Virulence 20150825 2

Despite recent advances in the field of Oncoimmunology, the success potential of immunomodulatory therapies against cancer remains to be elucidated. One of the reasons is the lack of understanding on the complex interplay between tumor growth dynamics and the associated immune system responses. Toward this goal, we consider a mathematical model of vascularized tumor growth and the corresponding effector cell recruitment dynamics. Bifurcation analysis allows for the exploration of model's dynamic ...[more]

PMID: 26305801

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