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Almeida2019 - Transcription-based circadian mechanism controls the duration of molecular clock states in response to signaling inputs

ABSTRACT: This is a transcriptional-based mathematical model centered on linear combinations of the clock controlled elements (CCEs): E-box, R-box and D-box, used to identify the essential interactions needed to generate phase opposition between the activating CLOCK:BMAL1 and the repressing PER:CRY complexes.

SUBMITTER: Johannes Meyer

PROVIDER: BIOMD0000000839 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Transcription-based circadian mechanism controls the duration of molecular clock states in response to signaling inputs.

Almeida Sofia S Chaves Madalena M Delaunay Franck F

Journal of theoretical biology 20190917

The molecular oscillator of the mammalian circadian clock consists in a dynamical network of genes and proteins whose main regulatory mechanisms occur at the transcriptional level. From a dynamical point of view, the mechanisms leading to an oscillatory solution with an orderly protein peak expression and a clear day/night phase distinction remain unclear. Our goal is to identify the essential interactions needed to generate phase opposition between the activating CLOCK:BMAL1 and the repressing ...[more]

PMID: 31539528

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