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Fribourg2014 - Model of influenza A virus infection dynamics of viral antagonism and innate immune response.


ABSTRACT: This is an ordinary differential equation mathematical model investigating the early responses of human monocyte-derived dendritic cells to infection by two H1N1 influenza A viruses of different clinical outcomes: pandemic A/California/4/2009 and seasonal A/New Caledonia/20/1999.

SUBMITTER: Johannes Meyer  

PROVIDER: BIOMD0000000889 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Model of influenza A virus infection: dynamics of viral antagonism and innate immune response.

Fribourg M M   Hartmann B B   Schmolke M M   Marjanovic N N   Albrecht R A RA   García-Sastre A A   Sealfon S C SC   Jayaprakash C C   Hayot F F  

Journal of theoretical biology 20140302


Viral antagonism of host responses is an essential component of virus pathogenicity. The study of the interplay between immune response and viral antagonism is challenging due to the involvement of many processes acting at multiple time scales. Here we develop an ordinary differential equation model to investigate the early, experimentally measured, responses of human monocyte-derived dendritic cells to infection by two H1N1 influenza A viruses of different clinical outcomes: pandemic A/Californ  ...[more]

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