Models

Dataset Information

0

Ferrel2011 - autonomous biochemical oscillator in cell cycle in Xenopus laevis v2


ABSTRACT: Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur, just as the theory of gravitation allows one to understand why cannonballs fly in parabolic arcs. The simplest examples of the eukaryotic cell cycle operate like autonomous oscillators. Here, we present the basic theory of oscillatory biochemical circuits in the context of the Xenopus embryonic cell cycle. We examine Boolean models, delay differential equation models, and especially ordinary differential equation (ODE) models. For ODE models, we explore what it takes to get oscillations out of two simple types of circuits (negative feedback loops and coupled positive and negative feedback loops). Finally, we review the procedures of linear stability analysis, which allow one to determine whether a given ODE model and a particular set of kinetic parameters will produce oscillations.

SUBMITTER: Matthieu MAIRE  

PROVIDER: BIOMD0000000936 | BioModels | 2024-09-02

REPOSITORIES: BioModels

altmetric image

Publications

Modeling the cell cycle: why do certain circuits oscillate?

Ferrell James E JE   Tsai Tony Yu-Chen TY   Yang Qiong Q  

Cell 20110301 6


Computational modeling and the theory of nonlinear dynamical systems allow one to not simply describe the events of the cell cycle, but also to understand why these events occur, just as the theory of gravitation allows one to understand why cannonballs fly in parabolic arcs. The simplest examples of the eukaryotic cell cycle operate like autonomous oscillators. Here, we present the basic theory of oscillatory biochemical circuits in the context of the Xenopus embryonic cell cycle. We examine Bo  ...[more]

Similar Datasets

2024-09-02 | BIOMD0000000937 | BioModels
2023-06-23 | GSE217461 | GEO
2023-06-23 | GSE217383 | GEO
2019-11-25 | PXD014843 | Pride
2024-09-02 | BIOMD0000000273 | BioModels
2018-07-31 | GSE115948 | GEO
2019-10-01 | E-MTAB-8168 | biostudies-arrayexpress
2024-10-15 | GSE267022 | GEO
2017-11-02 | GSE72652 | GEO
2017-11-02 | GSE72644 | GEO