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Mitrophanov2015 - Simulating extended Hockin Blood Coagulation Model under varied pH

ABSTRACT: Mathematical model of the blood coagulation cascade with new kinetic rates to simulate acidosis. Extended Hockin2002 model. Reused Mitrophanov2011 model with new parameters k: 5, 6, 7, 10, 15, 16, 17, 22, 26, 31, 32, 43 and 44.

SUBMITTER: Matthew Roberts

PROVIDER: BIOMD0000000951 | BioModels | 2024-09-02

REPOSITORIES: BioModels

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Publications

Mechanistic Modeling of the Effects of Acidosis on Thrombin Generation.

Mitrophanov Alexander Y AY Rosendaal Frits R FR Reifman Jaques J

Anesthesia and analgesia 20150801 2

<h4>Background</h4>Acidosis, a frequent complication of trauma and complex surgery, results from tissue hypoperfusion and IV resuscitation with acidic fluids. While acidosis is known to inhibit the function of distinct enzymatic reactions, its cumulative effect on the blood coagulation system is not fully understood. Here, we use computational modeling to test the hypothesis that acidosis delays and reduces the amount of thrombin generation in human blood plasma. Moreover, we investigate the sen ...[more]

PMID: 25839182

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