ABSTRACT:
This a model from the article:
A model of the action potential and underlying membrane currents in a rabbit
atrial cell.
Lindblad DS, Murphey CR, Clark JW, Giles WR. Am J Physiol
1996 Oct;271(4 Pt 2):H1666-96 8897964
,
Abstract:
We have developed a mathematical model of the rabbit atrial myocyte and have
used it in an examination of the ionic basis of the atrial action potential.
Available biophysical data have been incorporated into the model to quantify the
specific ultrastructural morphology, intracellular ion buffering, and time- and
voltage-dependent currents and transport mechanisms of the rabbit atrial cell.
When possible, mathematical expressions describing ionic currents identified in
rabbit atrium are based on whole cell voltage-clamp data from enzymatically
isolated rabbit atrial myocytes. This membrane model is coupled to equations
describing Na+, K+, and Ca2+ homeostasis, including the uptake and release of
Ca2+ by the sarcoplasmic reticulum and Ca2+ buffering. The resulting formulation
can accurately simulate the whole cell voltage-clamp data on which it is based
and provides fits to a family of rabbit atrial cell action potentials obtained
at 35 degrees C over a range of stimulus rates (0.2-3.0 Hz). The model is
utilized to provide a qualitative prediction of the intracellular Ca2+
concentration transient during the action potential and to illustrate the
interactions between membrane currents that underlie repolarization in the
rabbit atrial myocyte.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Lindblad DS, Murphey CR, Clark JW, Giles WR. (1996) - version=1.0
The original CellML model was created by:
Penny Noble
penny.noble@dpag.ox.ac.uk
The University of Oxford
This model originates from BioModels Database: A Database of Annotated Published Models (http://www.ebi.ac.uk/biomodels/). It is copyright (c) 2005-2011 The BioModels.net Team.
To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication
for more information.
In summary, you are entitled to use this encoded model in absolutely any manner you deem suitable, verbatim, or with modification, alone or embedded it in a larger context, redistribute it, commercially or not, in a restricted way or not.
.
To cite BioModels Database, please use: Li C, Donizelli M, Rodriguez N, Dharuri H, Endler L, Chelliah V, Li L, He E, Henry A, Stefan MI, Snoep JL, Hucka M, Le Novère N, Laibe C (2010) BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. BMC Syst Biol., 4:92.
Camille Laibe 