ABSTRACT:
This a model from the article:
Parasympathetic modulation of sinoatrial node pacemaker activity in rabbit
heart: a unifying model.
Demir SS, Clark JW, Giles WR. Am J Physiol
1999 Jun;276(6 Pt 2):H2221-44 10362707
,
Abstract:
We have extended our compartmental model [Am. J. Physiol. 266 (Cell Physiol.
35): C832-C852, 1994] of the single rabbit sinoatrial node (SAN) cell so that it
can simulate cellular responses to bath applications of ACh and isoprenaline as
well as the effects of neuronally released ACh. The model employs three
different types of muscarinic receptors to explain the variety of responses
observed in mammalian cardiac pacemaking cells subjected to vagal stimulation.
The response of greatest interest is the ACh-sensitive change in cycle length
that is not accompanied by a change in action potential duration or
repolarization or hyperpolarization of the maximum diastolic potential. In this
case, an ACh-sensitive K+ current is not involved. Membrane hyperpolarization
occurs in response to much higher levels of vagal stimulation, and this response
is also mimicked by the model. Here, an ACh-sensitive K+ current is involved.
The well-known phase-resetting response of the SAN cell to single and
periodically applied vagal bursts of impulses is also simulated in the presence
and absence of the beta-agonist isoprenaline. Finally, the responses of the SAN
cell to longer continuous trains of periodic vagal stimulation are simulated,
and this can result in the complete cessation of pacemaking. Therefore, this
model is 1) applicable over the full range of intensity and pattern of vagal
input and 2) can offer biophysically based explanations for many of the
phenomena associated with the autonomic control of cardiac pacemaking.
This model was taken from the CellML repository
and automatically converted to SBML.
The original model was:
Demir SS, Clark JW, Giles WR. (1999) - version03
The original CellML model was created by:
Lloyd, Catherine, May
c.lloyd@aukland.ac.nz
The University of Auckland
The Bioengineering Institute
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Vijayalakshmi Chelliah 