Dataset Information

Shlomi2011 - Warburg effect, metabolic model

ABSTRACT: Shlomi2011 - Warburg effect, metabolic model Using a genome-scale human metabolic network model accounting for stoichiometric and enzyme solvent capacity considerations, this model shows that the Warburg effect (a classical hallmark of cancer metabolism) is a direct consequence of the metabolic adaptation of cancer cells to increase biomass production rate. This model is described in the article: Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect. Shlomi T, Benyamini T, Gottlieb E, Sharan R, Ruppin E PLoS Computational Biology. 2011; 7(3):e1002018 Abstract: The Warburg effect - a classical hallmark of cancer metabolism - is a counter-intuitive phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production via glycolysis leading to lactate secretion, instead of relying primarily on more efficient energy production through mitochondrial oxidative phosphorylation, as most normal cells do. The causes for the Warburg effect have remained a subject of considerable controversy since its discovery over 80 years ago, with several competing hypotheses. Here, utilizing a genome-scale human metabolic network model accounting for stoichiometric and enzyme solvent capacity considerations, we show that the Warburg effect is a direct consequence of the metabolic adaptation of cancer cells to increase biomass production rate. The analysis is shown to accurately capture a three phase metabolic behavior that is observed experimentally during oncogenic progression, as well as a prominent characteristic of cancer cells involving their preference for glutamine uptake over other amino acids. This model is hosted on BioModels Database and identified by: MODEL1105100000 . To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models . To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Kieran Smallbone

PROVIDER: MODEL1105100000 | BioModels | 2005-01-01

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1105100000?filename=MODEL1105100000-biopax2.owl	Owl
	MODEL1105100000?filename=MODEL1105100000-biopax3.owl	Owl
	MODEL1105100000?filename=MODEL1105100000.m	Other
	MODEL1105100000?filename=MODEL1105100000.pdf	Pdf
	MODEL1105100000?filename=MODEL1105100000.png	Other

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Publications

Genome-scale metabolic modeling elucidates the role of proliferative adaptation in causing the Warburg effect.

Shlomi Tomer T Benyamini Tomer T Gottlieb Eyal E Sharan Roded R Ruppin Eytan E

PLoS computational biology 20110310 3

The Warburg effect--a classical hallmark of cancer metabolism--is a counter-intuitive phenomenon in which rapidly proliferating cancer cells resort to inefficient ATP production via glycolysis leading to lactate secretion, instead of relying primarily on more efficient energy production through mitochondrial oxidative phosphorylation, as most normal cells do. The causes for the Warburg effect have remained a subject of considerable controversy since its discovery over 80 years ago, with several ...[more]

PMID: 21423717

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