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Cao2010 - Epigenetic state of lysogeny in phage lambda

ABSTRACT: References: 1. Xiaomei Zhu, Lan Yin, Leroy Hood, David Galas and Ping Ao, Efficiency, Robustness and Stochasticity of Gene Regulatory networks in Systems biology: Lambda switch as a working example, 2006. 2. Adam Arkin, John Ross and Harley H. McAdams, Stochastic kinetic analysis of developmental pathway bifurcation in phage lambda-infected Escherichia coli cells, 1998, Genetics, 149: 1633-1648. 3. GenBank sequence: NC_001416 is the whole genome sequence of phage lambda.

SUBMITTER: Youfang Cao  

PROVIDER: MODEL1308080003 | BioModels | 2005-01-01

REPOSITORIES: BioModels

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Publications

Probability landscape of heritable and robust epigenetic state of lysogeny in phage lambda.

Cao Youfang Y   Lu Hsiao-Mei HM   Liang Jie J  

Proceedings of the National Academy of Sciences of the United States of America 20101011 43

Computational studies of biological networks can help to identify components and wirings responsible for observed phenotypes. However, studying stochastic networks controlling many biological processes is challenging. Similar to Schrödinger's equation in quantum mechanics, the chemical master equation (CME) provides a basic framework for understanding stochastic networks. However, except for simple problems, the CME cannot be solved analytically. Here we use a method called discrete chemical mas  ...[more]

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