Dataset Information

Mizuno2012 - AlzPathway: a comprehensive map of Alzheimer's disease

ABSTRACT: Mizuno2012 - AlzPathway: a comprehensive map of Alzheimer's disease Non-kinetic molecular map. Pure SBML file of AlzPathway provided by the authors as Additional file 5. This model is described in the article: AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease. Mizuno S, Iijima R, Ogishima S, Kikuchi M, Matsuoka Y, Ghosh S, Miyamoto T, Miyashita A, Kuwano R, Tanaka H. BMC Syst Biol 2012; 6: 52 Abstract: BACKGROUND: Alzheimer's disease (AD) is the most common cause of dementia among the elderly. To clarify pathogenesis of AD, thousands of reports have been accumulating. However, knowledge of signaling pathways in the field of AD has not been compiled as a database before. DESCRIPTION: Here, we have constructed a publicly available pathway map called "AlzPathway" that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 review articles related to AD, and have built an AD pathway map using CellDesigner. AlzPathway is currently composed of 1347 molecules and 1070 reactions in neuron, brain blood barrier, presynaptic, postsynaptic, astrocyte, and microglial cells and their cellular localizations. AlzPathway is available as both the SBML (Systems Biology Markup Language) map for CellDesigner and the high resolution image map. AlzPathway is also available as a web service (online map) based on Payao system, a community-based, collaborative web service platform for pathway model curation, enabling continuous updates by AD researchers. CONCLUSIONS: AlzPathway is the first comprehensive map of intra, inter and extra cellular AD signaling pathways which can enable mechanistic deciphering of AD pathogenesis. The AlzPathway map is accessible at http://alzpathway.org/. This model is hosted on BioModels Database and identified by: MODEL1504290001. To cite BioModels Database, please use: BioModels Database: An enhanced, curated and annotated resource for published quantitative kinetic models. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Audald Lloret i Villas

PROVIDER: MODEL1504290001 | BioModels | 2016-05-09

REPOSITORIES: BioModels

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			Action	DRS
	MODEL1504290001?filename=MODEL1504290001-biopax2.owl	Owl
	MODEL1504290001?filename=MODEL1504290001-biopax3.owl	Owl
	MODEL1504290001?filename=MODEL1504290001.m	Other
	MODEL1504290001?filename=MODEL1504290001.pdf	Pdf
	MODEL1504290001?filename=MODEL1504290001.png	Other

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Publications

AlzPathway: a comprehensive map of signaling pathways of Alzheimer's disease.

Mizuno Satoshi S Iijima Risa R Ogishima Soichi S Kikuchi Masataka M Matsuoka Yukiko Y Ghosh Samik S Miyamoto Tadashi T Miyashita Akinori A Kuwano Ryozo R Tanaka Hiroshi H

BMC systems biology 20120530

<h4>Background</h4>Alzheimer's disease (AD) is the most common cause of dementia among the elderly. To clarify pathogenesis of AD, thousands of reports have been accumulating. However, knowledge of signaling pathways in the field of AD has not been compiled as a database before.<h4>Description</h4>Here, we have constructed a publicly available pathway map called "AlzPathway" that comprehensively catalogs signaling pathways in the field of AD. We have collected and manually curated over 100 revie ...[more]

PMID: 22647208

Publication: 1/107

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