Dataset Information

Martinez-Guimera2017 - Generic redox signalling model without negative regulation (Model 1)

ABSTRACT: Martinez-Guimera2017 - Generic redox signalling model without negative regulation (Model 1) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, Shanley DP. Mech. Ageing Dev. 2017 Nov; : Abstract: The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. In this work, we adopt a theoretical perspective as an exploratory and explanatory approach to examine how chronic oxidative stress can interfere with signal processing by redox signalling pathways in the cell. We report that constitutive signals can give rise to a 'molecular habituation' effect that can prime for a gradual loss of biological function. This is because a constitutive signal in the environment has the potential to reduce the responsiveness of a signalling pathway through the prolonged activation of negative regulators. Additionally, we demonstrate how this phenomenon is likely to occur in different signalling pathways exposed to persistent signals and furthermore at different levels of biological organisation. This model is hosted on BioModels Database and identified by: MODEL1710260000. To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

SUBMITTER: Alvaro Martinez Guimera

PROVIDER: MODEL1710260000 | BioModels |

REPOSITORIES: BioModels

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Dataset's files

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			Action	DRS
	MODEL1710260000?filename=MODEL1710260000-biopax2.owl	Owl
	MODEL1710260000?filename=MODEL1710260000-biopax3.owl	Owl
	MODEL1710260000?filename=MODEL1710260000.m	Other
	MODEL1710260000?filename=MODEL1710260000.png	Other
	MODEL1710260000?filename=MODEL1710260000.sci	Other

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Publications

'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age.

Martinez Guimera Alvaro A Welsh Ciaran M CM Proctor Carole J CJ McArdle Anne A Shanley Daryl P DP

Mechanisms of ageing and development 20171114

The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. In this work, we adopt a theoretical pe ...[more]

PMID: 29146308

Similar Datasets

Project description:Martinez-Guimera2017 - Generic redox signalling model with negative feedback regulation (Model 2) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, Shanley DP. Mech. Ageing Dev. 2017 Nov; : Abstract: The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. In this work, we adopt a theoretical perspective as an exploratory and explanatory approach to examine how chronic oxidative stress can interfere with signal processing by redox signalling pathways in the cell. We report that constitutive signals can give rise to a 'molecular habituation' effect that can prime for a gradual loss of biological function. This is because a constitutive signal in the environment has the potential to reduce the responsiveness of a signalling pathway through the prolonged activation of negative regulators. Additionally, we demonstrate how this phenomenon is likely to occur in different signalling pathways exposed to persistent signals and furthermore at different levels of biological organisation. This model is hosted on BioModels Database and identified by: MODEL1710260001. To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Project description:Martinez-Guimera2017 - Generic redox signalling model with negative feedforward regulation (Model 3) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, Shanley DP. Mech. Ageing Dev. 2017 Nov; : Abstract: The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. In this work, we adopt a theoretical perspective as an exploratory and explanatory approach to examine how chronic oxidative stress can interfere with signal processing by redox signalling pathways in the cell. We report that constitutive signals can give rise to a 'molecular habituation' effect that can prime for a gradual loss of biological function. This is because a constitutive signal in the environment has the potential to reduce the responsiveness of a signalling pathway through the prolonged activation of negative regulators. Additionally, we demonstrate how this phenomenon is likely to occur in different signalling pathways exposed to persistent signals and furthermore at different levels of biological organisation. This model is hosted on BioModels Database and identified by: MODEL1710260002. To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Project description:Martinez-Guimera2017 - Generic negative feedback circuit (Model 4) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, Shanley DP. Mech. Ageing Dev. 2017 Nov; : Abstract: The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. In this work, we adopt a theoretical perspective as an exploratory and explanatory approach to examine how chronic oxidative stress can interfere with signal processing by redox signalling pathways in the cell. We report that constitutive signals can give rise to a 'molecular habituation' effect that can prime for a gradual loss of biological function. This is because a constitutive signal in the environment has the potential to reduce the responsiveness of a signalling pathway through the prolonged activation of negative regulators. Additionally, we demonstrate how this phenomenon is likely to occur in different signalling pathways exposed to persistent signals and furthermore at different levels of biological organisation. This model is hosted on BioModels Database and identified by: MODEL1710260003. To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.

Project description:Martinez-Guimera2017 - Generic negative feedforward circuit (Model 5) This model is described in the article: 'Molecular habituation' as a potential mechanism of gradual homeostatic loss with age. Martinez Guimera A, Welsh CM, Proctor CJ, McArdle A, Shanley DP. Mech. Ageing Dev. 2017 Nov; : Abstract: The ability of reactive oxygen species (ROS) to cause molecular damage has meant that chronic oxidative stress has been mostly studied from the point of view of being a source of toxicity to the cell. However, the known duality of ROS molecules as both damaging agents and cellular redox signals implies another perspective in the study of sustained oxidative stress. This is a perspective of studying oxidative stress as a constitutive signal within the cell. In this work, we adopt a theoretical perspective as an exploratory and explanatory approach to examine how chronic oxidative stress can interfere with signal processing by redox signalling pathways in the cell. We report that constitutive signals can give rise to a 'molecular habituation' effect that can prime for a gradual loss of biological function. This is because a constitutive signal in the environment has the potential to reduce the responsiveness of a signalling pathway through the prolonged activation of negative regulators. Additionally, we demonstrate how this phenomenon is likely to occur in different signalling pathways exposed to persistent signals and furthermore at different levels of biological organisation. This model is hosted on BioModels Database and identified by: MODEL1710260004. To cite BioModels Database, please use: Chelliah V et al. BioModels: ten-year anniversary. Nucl. Acids Res. 2015, 43(Database issue):D542-8. To the extent possible under law, all copyright and related or neighbouring rights to this encoded model have been dedicated to the public domain worldwide. Please refer to CC0 Public Domain Dedication for more information.