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Seif2019 - Strain-specific metabolic models of Salmonella

ABSTRACT: Seif, 2019 - Systems biology and pangenome of Salmonella O-antigens Strain-specific metabolic models of Salmonella strains updated with O-antigen metabolic pathways. Locus-tags are updated in this version of the models to include both the prokka annotations and the refseq locus tags.

SUBMITTER: Yara Seif

PROVIDER: MODEL1907100002 | BioModels | 2019-09-11

REPOSITORIES: BioModels

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Publications

Systems Biology and Pangenome of <i>Salmonella</i> O-Antigens.

Seif Yara Y Monk Jonathan M JM Machado Henrique H Kavvas Erol E Palsson Bernhard O BO

mBio 20190827 4

O-antigens are glycopolymers in lipopolysaccharides expressed on the cell surface of Gram-negative bacteria. Variability in the O-antigen structure constitutes the basis for the establishment of the serotyping schema. We pursued a two-pronged approach to define the basis for O-antigen structural diversity. First, we developed a bottom-up systems biology approach to O-antigen metabolism by building a reconstruction of <i>Salmonella</i> O-antigen biosynthesis and used it to (i) update 410 existing ...[more]

PMID: 31455646

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