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Khan2018 - Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2

ABSTRACT: This is a ordinary differential equation-based model of the eukaryotic translation initiation factor (eIF2) phosphorylation pathway, a pathway important for regulating protein synthesis activity in eukaryotic cells. This model is geared towards identification the principal robustness-conferring features of the pathway.

SUBMITTER: Johannes Meyer

PROVIDER: MODEL1911120001 | BioModels | 2019-11-13

REPOSITORIES: BioModels

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Publications

Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2.

Khan Mohammad Farhan MF Spurgeon Sarah S von der Haar Tobias T

Journal of theoretical biology 20180221

Phosphorylation of eukaryotic translation initiation factor 2 (eIF2) is one of the best studied and most widely used means for regulating protein synthesis activity in eukaryotic cells. This pathway regulates protein synthesis in response to stresses, viral infections, and nutrient depletion, among others. We present analyses of an ordinary differential equation-based model of this pathway, which aim to identify its principal robustness-conferring features. Our analyses indicate that robustness ...[more]

PMID: 29476830

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