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McFarland2020 - Synthetase sequestration Model:a combined translation and tRNA charging cycle

ABSTRACT: The Synthetase Sequestration Model (SSM) is a simplified translation model that considers explicitly two main steps in the process of tRNA aminoacylation: first, the tRNA is bound by the aminoacyl tRNA synthetase, and in a second step, the amino acid is attached to the tRNA. The tRNA then participates in the translation reaction, becoming deacylated as a result. The tRNA exists in states bound, charged and uncharged. In the bound state, the tRNA is bound to the synthetase but uncharged, i.e., the tRNA is sequestered by the synthetase. The model predicts how the balance between the three different tRNA states (empty, bound and charged) changes depending on aminoacyl tRNA synthetase availability.

SUBMITTER: Ian Stansfield

PROVIDER: MODEL2001080005 | BioModels | 2020-02-05

REPOSITORIES: BioModels

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	MODEL2001080005?filename=README-SSM.txt	Txt
	MODEL2001080005?filename=Synthetase_sequestration_Model.zip	Other

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