Ontology highlight
ABSTRACT:
SUBMITTER: Krishna Kumar Tiwari
PROVIDER: MODEL2003030003 | BioModels | 2020-03-05
REPOSITORIES: BioModels
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MODEL2003030003?filename=Wu2017_v1.cps | Other | |||
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The AAPS journal 20120306 2
Our objective was to determine the pharmacokinetics, bioavailability and lymph node uptake of the monoclonal antibody bevacizumab, labeled with the near-infrared (IR) dye 800CW, after intravenous (IV) and subcutaneous (SC) administration in mice. Fluorescence imaging and enzyme-linked immunosorbent assay (ELISA) assays were developed and validated to measure the concentration of bevacizumab in plasma. The bevacizumab-IRDye conjugate remained predominantly intact in plasma and in lymph node homog ...[more]