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Gidvani2012 - DNA replication initiation model in S. Cevevisiae

ABSTRACT: A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations. Model is encoded by Matthew Maire and submitted in BioModels by Krishna Kumar Tiwari.

SUBMITTER: Krishna Kumar Tiwari  

PROVIDER: MODEL2003180001 | BioModels | 2020-05-06

REPOSITORIES: BioModels

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A quantitative model of the initiation of DNA replication in Saccharomyces cerevisiae predicts the effects of system perturbations.

Gidvani Rohan D RD   Sudmant Peter P   Li Grace G   DaSilva Lance F LF   McConkey Brendan J BJ   Duncker Bernard P BP   Ingalls Brian P BP  

BMC systems biology 20120627

<h4>Background</h4>Eukaryotic cell proliferation involves DNA replication, a tightly regulated process mediated by a multitude of protein factors. In budding yeast, the initiation of replication is facilitated by the heterohexameric origin recognition complex (ORC). ORC binds to specific origins of replication and then serves as a scaffold for the recruitment of other factors such as Cdt1, Cdc6, the Mcm2-7 complex, Cdc45 and the Dbf4-Cdc7 kinase complex. While many of the mechanisms controlling  ...[more]

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