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Novak1998 - Mathematical model of fission yeast cell cycle

ABSTRACT: Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions. Model encoded by Matthieu Maire and submitted to BioModels by Krishna kumar Tiwari.

SUBMITTER: Krishna Kumar Tiwari

PROVIDER: MODEL2003190004 | BioModels | 2020-03-19

REPOSITORIES: BioModels

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Mathematical model of the fission yeast cell cycle with checkpoint controls at the G1/S, G2/M and metaphase/anaphase transitions.

Novak B B Csikasz-Nagy A A Gyorffy B B Chen K K Tyson J J JJ

Biophysical chemistry 19980501 1-2

All events of the fission yeast cell cycle can be orchestrated by fluctuations of a single cyclin-dependent protein kinase, the Cdc13/Cdc2 heterodimer. The G1/S transition is controlled by interactions of Cdc13/Cdc2 and its stoichiometric inhibitor, Rum1. The G2/M transition is regulated by a kinase-phosphatase pair, Wee1 and Cdc25, which determine the phosphorylation state of the Tyr-15 residue of Cdc2. The meta/anaphase transition is controlled by interactions between Cdc13/Cdc2 and the anapha ...[more]

PMID: 9652094

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