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DiCenzo2020 - Sinorhizobium meliloti 1021 genome-scale metabolic model

ABSTRACT: An updated representation of S. meliloti metabolism that was manually-curated and encompasses information from 240 literature sources, which includes transposon-sequencing (Tn-seq) data and Phenotype MicroArray data for wild-type and mutant strains.

SUBMITTER: George C diCenzo

PROVIDER: MODEL2003240001 | BioModels | 2020-06-01

REPOSITORIES: BioModels

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Publications

Genome-scale metabolic reconstruction of the symbiosis between a leguminous plant and a nitrogen-fixing bacterium.

diCenzo George C GC Tesi Michelangelo M Pfau Thomas T Mengoni Alessio A Fondi Marco M

Nature communications 20200522 1

The mutualistic association between leguminous plants and endosymbiotic rhizobial bacteria is a paradigmatic example of a symbiosis driven by metabolic exchanges. Here, we report the reconstruction and modelling of a genome-scale metabolic network of Medicago truncatula (plant) nodulated by Sinorhizobium meliloti (bacterium). The reconstructed nodule tissue contains five spatially distinct developmental zones and encompasses the metabolism of both the plant and the bacterium. Flux balance analys ...[more]

PMID: 32444627

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