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Soh2020 - Spatio-temporal morphogen gradient and BMP signaling

ABSTRACT: This model couples BMP morphogen gradient formation with Smad signaling in zebrafish and reproduces Fig.3B of the referenced paper. mBMP4 diffuses and forms a morphogen gradient in the host tissue where differential signal transduction kinetics for pSmad2 versus pSmad5 lead to narrow (pSmad2) versus wide (pSmad5) signal activity ranges in response to the same morphogen gradient (mBMP4) as input. The model file is in MorpheusML format and can be opened in the free, open-source multicellular modeling software Morpheus (https://morpheus.gitlab.io) to simulate the time course (movie) of the spatio-temporal dynamics. Further optional plots of the radial solution profile and the time courses of mean concentrations over the domain are included and temporarily inactivated in the model file, in section Analysis.

SUBMITTER: Peter Brusch

PROVIDER: MODEL2012070002 | BioModels | 2021-10-06

REPOSITORIES: BioModels

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			Action	DRS
	MODEL2012070002?filename=BMP_signaling.png	Other
	MODEL2012070002?filename=BMP_signaling.xml	Xml
	MODEL2012070002?filename=Soh2020_Fig3B.png	Other

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Publications

Integration of Nodal and BMP Signaling by Mutual Signaling Effector Antagonism.

Soh Gary Huiming GH Pomreinke Autumn Penecilla AP Müller Patrick P

Cell reports 20200401 1

Opposing sources of bone morphogenetic protein (BMP) and Nodal signaling molecules are sufficient to induce the formation of a full axis in zebrafish embryos. To address how these signals orchestrate patterning, we transplant sources of fluorescently tagged Nodal and BMP into zebrafish embryos, robustly inducing the formation of secondary axes. Nodal and BMP signal non-cell-autonomously and form similar protein gradients in this context, but the signaling range of Nodal (pSmad2) is shorter than ...[more]

PMID: 32268105

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