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Corral2021 - Interplay between SMAD2 and STAT5A regulating IL-17A/F expression in Th cells.

ABSTRACT: IL-17A and F are critical cytokines in anti-microbial immunity but also contribute to auto-immune pathologies. Recent evidence suggests that they may be differentially produced by T-helper (Th) cells but the underlying mechanisms remain unknown. To address this question, a logical model containing 82 components and 136 regulatory links was developed and calibrated with original flow cytometry data using naive CD4+ T cells in conditions inducing either IL-17A or F. Model analyses led to the identification of the transcription factors NFAT2A, STAT5A and Smad2 as key components explaining the differential expression of IL-17A and IL-17F, with STAT5A controlling IL-17F expression, and an interplay of NFAT2A, STAT5A and Smad2 controlling IL-17A expression.

OTHER RELATED OMICS DATASETS IN: PRJNA246420PRJNA146093PRJNA117127PRJNA305162PRJNA142285PRJNA136635GSE26553PRJNA142287PRJNA110559PRJNA188245PRJNA188248PRJNA188243PRJNA188244PRJNA188241

SUBMITTER: Denis Thieffry  

PROVIDER: MODEL2101150001 | BioModels | 2021-04-06

REPOSITORIES: BioModels

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Publications

Both integrated and differential regulation of components of the IL-2/IL-2 receptor system.

Kim Hyoung Pyo HP   Imbert Jean J   Leonard Warren J WJ  

Cytokine & growth factor reviews 20060905 5

Interleukin-2 was discovered in 1976 as a T-cell growth factor. It was the first type I cytokine cloned and the first for which a receptor component was cloned. Its importance includes its multiple actions, therapeutic potential, and lessons for receptor biology, with three components differentially combining to form high, intermediate, and low-affinity receptors. IL-2Ralpha and IL-2Rbeta, respectively, are markers for double-negative thymocytes and regulatory T-cells versus memory cells. gamma(  ...[more]

PMID: 16911870

Publication: 1/86

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