Models

Dataset Information

0

HesseMuellerRelogio2023 - Timing treatment toxicity of the cancer drug irinotecan based on circadian gene expression profiles


ABSTRACT: Chronotherapy demands that patients are treated at a particular time of the day in order to maximize treatment effects and minimize side effects. Chronotherapy can be personalized by taking into account the patient's circadian rhythm as measured by a repetitive sampling of gene expression over the day. As a proof of concept, the submitted model links circadian gene expression to the diurnal toxicity profile of the cancer drug irinotecan. The model is based on MODEL2109140001; it implements a transcription-translation network model of the core clock and additional genes associated with irinotecan metabolism and links this to a model of the pharmacokinetics and -dynamics (PK-PD) of irinotecan. The submitted model refines network connections of the gene regulatory network and adds a treatment-induced increase in UGT1A1 and a transient increase in the apoptosis rate in response to treatment for the PK-PD part.

SUBMITTER: Janina Hesse  

PROVIDER: MODEL2305270001 | BioModels | 2023-06-27

REPOSITORIES: BioModels

Similar Datasets

2022-08-06 | GSE210512 | GEO
2022-06-14 | GSE165104 | GEO
2019-11-13 | MODEL1910240001 | BioModels
2022-02-15 | PXD028283 | Pride
2019-05-14 | GSE119668 | GEO
2020-05-30 | GSE148280 | GEO
2020-05-30 | GSE148253 | GEO
| b3b | Physiome Model Repository
2016-06-10 | E-GEOD-83188 | biostudies-arrayexpress
2016-06-10 | GSE83188 | GEO