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Carter2023 - Genome-scale metabolic model of Photorhabdus asymbiotica.

ABSTRACT: Photorhabdus asymbiotica is an emerging human pathogen shown to display a dramatic metabolic shift when growing at a temperature associated with mammalian body temperature compared to the temperature of an insect, its typical host. This genome-scale metabolic model is one the first steps to investigate the metabolism of this organism further in an attempt to elucidate the metabolic adaptations facilitating the survival of this pathogen at higher temperatures.

SUBMITTER: Elena Carter

PROVIDER: MODEL2309110001 | BioModels | 2024-08-02

REPOSITORIES: BioModels

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A temperature-induced metabolic shift in the emerging human pathogen Photorhabdus asymbiotica.

Carter Elena Lucy EL Waterfield Nicholas R NR Constantinidou Chrystala C Alam Mohammad Tauqeer MT

mSystems 20241024 11

Photorhabdus is a bacterial genus containing both insect and emerging human pathogens. Most insect-restricted species display temperature restriction, unable to grow above 34°C, while Photorhabdus asymbiotica can grow at 37°C to infect mammalian hosts and cause Photorhabdosis. Metabolic adaptations have been proposed to facilitate the survival of this pathogen at higher temperatures, yet the biological mechanisms underlying these are poorly understood. We have reconstructed an exte ...[more]

PMID: 39445821

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