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Haiman2025 - RBC-GEM, v1.2.0, proteome-constrained

ABSTRACT: Initial submission of the proteome-constrained RBC-GEM genome-scale metabolic model, version 1.2.0. Constraints were formulated using a modified version of the OVERLAY computational pipeline (PMID: 36650525). The model is parameterized using the REDS RBC Omics dataset (PMID: 38964323). Flux bounds of the representative model were set using the minimum/maximum values, determined via flux variability analyses, across all generated context-specific proteome-constrained models.

SUBMITTER: Zachary B Haiman

PROVIDER: MODEL2501130001 | BioModels | 2025-04-07

REPOSITORIES: BioModels

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Publications

Identification and characterization of a Na(+)-independent neutral amino acid transporter that associates with the 4F2 heavy chain and exhibits substrate selectivity for small neutral D- and L-amino acids.

Fukasawa Y Y Segawa H H Kim J Y JY Chairoungdua A A Kim D K DK Matsuo H H Cha S H SH Endou H H Kanai Y Y

The Journal of biological chemistry 20000301 13

A cDNA was isolated from the mouse brain that encodes a novel Na(+)-independent neutral amino acid transporter. The encoded protein, designated as Asc-1 (asc-type amino acid transporter 1), was found to be structurally related to recently identified mammalian amino acid transporters for the transport systems L, y(+)L, x(C)(-), and b(0,+), which are linked, via a disulfide bond, to the type II membrane glycoproteins, 4F2 heavy chain (4F2hc), or rBAT (related to b(0,+) amino acid transporter). Asc ...[more]

PMID: 10734121

Publication: 1/5

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Haiman2025 - RBC-GEM v1.2.0

Project description:Initial submission of RBC-GEM genome-scale metabolic model, version 1.2.0.

2025-04-07 | MODEL2410170001 | BioModels

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DMSO enhances electrospray response boosting sensitivity of proteomic experiments

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Single-cell RNA sequencing of chicken skin

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Agilent 244A aCGH array for comparison of lung tumor CNA to high-throughput sequencing data

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