Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling by array of Mycobacterium avium subspecies paratuberculosis treated with rhodanine agent D157070


ABSTRACT: Data is also available from BuG@Sbase

INSTRUMENT(S): NanoDrop

ORGANISM(S): Mycobacterium avium

SUBMITTER:  

PROVIDER: E-BUGS-92 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

A rhodanine agent active against non-replicating intracellular Mycobacterium avium subspecies paratuberculosis.

Bull Tim J TJ   Linedale Richard R   Hinds Jason J   Hermon-Taylor John J  

Gut pathogens 20091223


<h4>Background</h4>Antibiotic therapy targeting chronic mycobacterial disease is often ineffective due to problems with the emergence of drug resistance and non-replicating persistent intracellular antibiotic resistant phenotypes. Strategies which include agents able to enhance host cell killing mechanisms could represent an alternative to conventional methods with the potential for host clearance if active against dormant phenotypes. Investigations of agents with potential activity against non-  ...[more]

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