Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

Dataset Information

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Transcription profiling of pig aortic endothelium taken from regions of disturbed and undisturbed flow


ABSTRACT: This study investigates the role of endothelial cell (EC) gene expression in the focal origin of atherosclerosis, particularly in response to local hemodynamics. Differential gene expression was profiled in EC isolated from athero-susceptible and athero-protected regions of the normal pig aorta. Specifically, a region of disturbed flow (DF, the inner aortic arch) was compared to a region of undisturbed flow (UF, descending thoracic aorta). Linearly amplified RNA was used to screen nylon filter arrays of 13,824 human cDNAs.

ORGANISM(S): Sus scrofa

SUBMITTER: unknown unknown 

PROVIDER: E-CBIL-17 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Coexisting proinflammatory and antioxidative endothelial transcription profiles in a disturbed flow region of the adult porcine aorta.

Passerini Anthony G AG   Polacek Denise C DC   Shi Congzhu C   Francesco Nadeene M NM   Manduchi Elisabetta E   Grant Gregory R GR   Pritchard William F WF   Powell Steven S   Chang Gary Y GY   Stoeckert Christian J CJ   Davies Peter F PF  

Proceedings of the National Academy of Sciences of the United States of America 20040201 8


In the arterial circulation, regions of disturbed flow (DF), which are characterized by flow separation and transient vortices, are susceptible to atherogenesis, whereas regions of undisturbed laminar flow (UF) appear protected. Coordinated regulation of gene expression by endothelial cells (EC) may result in differing regional phenotypes that either favor or inhibit atherogenesis. Linearly amplified RNA from freshly isolated EC of DF (inner aortic arch) and UF (descending thoracic aorta) region  ...[more]

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