Ontology highlight
ABSTRACT:
ORGANISM(S): Sus scrofa
SUBMITTER: unknown unknown
PROVIDER: E-CBIL-17 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Passerini Anthony G AG Polacek Denise C DC Shi Congzhu C Francesco Nadeene M NM Manduchi Elisabetta E Grant Gregory R GR Pritchard William F WF Powell Steven S Chang Gary Y GY Stoeckert Christian J CJ Davies Peter F PF
Proceedings of the National Academy of Sciences of the United States of America 20040201 8
In the arterial circulation, regions of disturbed flow (DF), which are characterized by flow separation and transient vortices, are susceptible to atherogenesis, whereas regions of undisturbed laminar flow (UF) appear protected. Coordinated regulation of gene expression by endothelial cells (EC) may result in differing regional phenotypes that either favor or inhibit atherogenesis. Linearly amplified RNA from freshly isolated EC of DF (inner aortic arch) and UF (descending thoracic aorta) region ...[more]