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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of non-obese diabetic (NOD) mice with or without the scid mutation and BDC2.5 TCR gene knock-in to study T-cell mediated B-cell damage and repair

ABSTRACT: Dynamic interaction between T-cell mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mice.

INSTRUMENT(S): Affymetrix Fluidics Station 400

ORGANISM(S): Mus musculus

SUBMITTER: Jonathan Katz

PROVIDER: E-CBIL-18 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Dynamic interaction between T cell-mediated beta-cell damage and beta-cell repair in the run up to autoimmune diabetes of the NOD mouse.

Vukkadapu Sankaranand S SS Belli Jenine M JM Ishii Koji K Jegga Anil G AG Hutton John J JJ Aronow Bruce J BJ Katz Jonathan D JD

Physiological genomics 20050125 2

In type 1 diabetes mellitus (T1DM), also known as autoimmune diabetes, the pathogenic destruction of the insulin-producing pancreatic beta-cells is under the control of and influenced by distinct subsets of T lymphocytes. To identify the critical genes expressed by autoimmune T cells, antigen presenting cells, and pancreatic beta-cells during the evolution of T1DM in the nonobese diabetic (NOD) mouse, and the genetically-altered NOD mouse (BDC/N), we used functional genomics. Microarray analysis ...[more]

PMID: 15671250

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