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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of fat and normal adipocytes from insulin receptor knockout mice sorted into small and large cells

ABSTRACT: Mice with fat-specific disruption of the insulin receptor gene (FIRKO mice) have low fat mass, and are protected against obesity and obesity-related glucose intolerance. FIRKO mice also exhibit polarization of adipocytes into populations of large and small cells. Other PubMed identifiers for this study: 15131120,12110165,15131119

INSTRUMENT(S): Affymetrix Fluidics Station 400

ORGANISM(S): Mus musculus

SUBMITTER: Ronald Kahn

PROVIDER: E-CBIL-23 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Intrinsic heterogeneity in adipose tissue of fat-specific insulin receptor knock-out mice is associated with differences in patterns of gene expression.

Blüher Matthias M Patti Mary-Elizabeth ME Gesta Stephane S Kahn Barbara B BB Kahn C Ronald CR

The Journal of biological chemistry 20040506 30

Mice with a fat-specific insulin receptor knock-out (FIRKO) have reduced adipose tissue mass, are protected against obesity, and have an extended life span. White adipose tissue of FIRKO mice is also characterized by a polarization into two major populations of adipocytes, one small (<50 microm) and one large (>100 microm), which differ with regard to basal triglyceride synthesis and lipolysis, as well as in the expression of fatty acid synthase, sterol regulatory element-binding protein 1c, and ...[more]

PMID: 15131119

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