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Transcription profiling of human heart with heart failure due to ischemic cardiomyopathy or dilated cardiomyopathy

ABSTRACT: End stage heart failure due to ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) have similar characteristics, enlargement of the ventricles, relatively thin-walled ventricle, which leads to a limited contraction force and blood loading. Nevertheless, the response for present therapeutics is very variable and the prognosis is still very bad for ICM and DCM in general. Thus, the ability to differentiate the etiologies of heart failure based structural and physiological changes of the heart would be a step forward to enhance the specificity and the success of given therapy.

ORGANISM(S): Homo sapiens

DISEASE(S): normal

SUBMITTER: Ruprecht Kuner 

PROVIDER: E-CVDE-1 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Genomic analysis reveals poor separation of human cardiomyopathies of ischemic and nonischemic etiologies.

Kuner Ruprecht R   Barth Andreas S AS   Ruschhaupt Markus M   Buness Andreas A   Zwermann Ludwig L   Kreuzer Eckart E   Steinbeck Gerhard G   Poustka Annemarie A   Sültmann Holger H   Nabauer Michael M  

Physiological genomics 20080422 1

Clinically, the differentiation between ischemic (ICM) and nonischemic (NICM) human cardiomyopathies is highly relevant, because ICM and NICM differ with respect to prognosis and certain aspects of pharmacological therapy, despite a common final phenotype characterized by ventricular dilatation and reduced contractility. So far, it is unclear whether microarray-based signatures can be used to infer the etiology of heart failure. Using three different classification algorithms, we independently a  ...[more]