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Dilated Cardiomyopathy in Dobermans and Boxers

ABSTRACT: This study attempts at investigating the changes in cardiac gene expression that occur in Dilated Cardiomyopathy (DCM). DCM in Dobermans and Boxers are the focus of this study. Control heart tissue as well as Pacing tissue used is from mongrel dogs. Keywords: control vs pacing vs disease; strain specific disease 3 Dobermans-DCM, 4 Boxers-DCM, 3 mongrels-control and 3 mongrels-pacing

ORGANISM(S): Canis lupus familiaris

SUBMITTER: Sridar Chittur

PROVIDER: E-GEOD-11015 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Arrhythmogenic right ventricular cardiomyopathy in Boxer dogs is associated with calstabin2 deficiency.

Oyama Mark A MA Reiken Steve S Lehnart Stephan E SE Chittur Sridar V SV Meurs Kathryn M KM Stern Joshua J Marks Andrew R AR

Journal of veterinary cardiology : the official journal of the European Society of Veterinary Cardiology 20080602 1

<h4>Objective</h4>To examine the presence and effect of calstabin2-deficiency in Boxer dogs with arrhythmogenic right ventricular cardiomyopathy (ARVC).<h4>Animals</h4>Thirteen Boxer dogs with ARVC.<h4>Materials and methods</h4>Tissue samples were collected for histopathology, oligonucleotide microarray, PCR, immunoelectrophoresis, ryanodine channel immunoprecipitation and single-channel recordings, and calstabin2 DNA sequencing.<h4>Results</h4>In cardiomyopathic Boxer dogs, myocardial calstabin ...[more]

PMID: 18515204

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Dilated Cardiomyopathy in Dobermans and Boxers

Project description:This study attempts at investigating the changes in cardiac gene expression that occur in Dilated Cardiomyopathy (DCM). DCM in Dobermans and Boxers are the focus of this study. Control heart tissue as well as Pacing tissue used is from mongrel dogs. Keywords: control vs pacing vs disease; strain specific disease

2008-05-08 | GSE11015 | GEO

Expression in myocardial tissues of Great Dane dogs with cardiomyopathy

Project description:Oligonucleotide microarray analysis of left ventricular tissues from 3 Great dane dogs with dilated cardiomyopathy and 3 control dogs was performed. Three hundred and twenty three differentially expressed transcripts were detected. The transcript demonstrating the highest degree of upregulation was FKBP12.6 (calstabin2) and the transcript with the greatest amount of down regulation was triadin. Both of these transcripts are critical to proper functioning of the cardiac ryanodine receptor. Abnormalities of both calstabin2 and triadin have been reported in humans with heart disease. Further investigation into the role of calstabin2 and triadin in canine cardiomyopathy is warranted, and the canine disease may serve as a model of human disease. Keywords: control vs diseased 3 controls and 3 affected

2010-04-09 | E-GEOD-16049 | biostudies-arrayexpress

Dilated Cardiomyopathy and Non Failing Biopsies

Project description:Dilated cardiomyopathy (DCM) is a common cause of heart failure and a leading cause of cardiac transplantation in western countries. The robust predictive expression profile of cardiomyopathic and NF hearts as well as the functional classification can help to identify promising candidates for DCM and may improve the early diagnosis of cardiomyopathy. Keywords: disease state analysis

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Project description:Dilated cardiomyopathy vs Myocarditis

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Transcription profiling of human heart with heart failure due to ischemic cardiomyopathy or dilated cardiomyopathy

Project description:End stage heart failure due to ischemic cardiomyopathy (ICM) and dilated cardiomyopathy (DCM) have similar characteristics, enlargement of the ventricles, relatively thin-walled ventricle, which leads to a limited contraction force and blood loading. Nevertheless, the response for present therapeutics is very variable and the prognosis is still very bad for ICM and DCM in general. Thus, the ability to differentiate the etiologies of heart failure based structural and physiological changes of the heart would be a step forward to enhance the specificity and the success of given therapy.

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Project description:Dilated Cardiomyopathy

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Project description:To investigate the physiological characteristics of cardiac fibroblasts (CF) from pediatric dilated cardiomyopathy (DCM) patients, CFs were harvested from left ventricular free wall at the heart transplantation. We then performed RNA-seq for 7 different lines of CFs.

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Differential expression of microRNAs and their target genes in Dilated Cardiomyopathy

Project description:We aimed to identify aberrantly expressed microRNA and mRNA expression profiles of dilated cardiomyopathy (DCM) and explore their potential functions, 10 DCM blood samples and paired healthy control blood samples underwent RNA-sequence.

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Differential expression of mRNA expressed in healthy and Dobermanns affected with dilated cardiomyopathy

Project description:Dilated cardiomyopathy (DCM) affects both humans and dogs and is associated with shortened life-span and sudden death. Dobermanns have previously been described with genetic variants assoociated with disease, and in this study we wanted to study gene specific expression differences between healthy and DCM-affected individuals. Included in the cohort were nine dogs, four healthy and five clinical and pre-clinical cases. The cases were sampled shortly after death (within 30 minutes) and samples snap-frozen from different compartments of the heart. Prior to euthanization the dogs were evaluted by ultrasound, and histological evaluation of the tissues were also performed after tissue sampling for proper phenotyping. In this study tissues from the septal wall was used for mRNA-sequencing. The samples were prepared according to Illuminas protocol for library preparation (TruSeq® Stranded mRNA Library) and sequenced on an Illumina NextSeq 550. Following basecalling at Illumina BaseSpace FASTQ-files were proceessed through a pipeline of Trimmomatic, SortMeRNA, STAR, edgeR and DESeq2, with quality controlls in between at relevant steps with FastQC. No significantly differentially expressed genes could be identified with either edgeR or DESeq2, which may be due to too few samples in each group. The sequencing data was also used for visual inspection of potential splice variants associated with genetic variants identified in an other cohourt of DCM-affected Dobermanns evaluated with GWAS. A novel splice-variant identified in RNF207 causing a frame-shame shift excluding three codons, was confirmed in the present mRNA-seq data.

2023-11-16 | E-MTAB-12151 | biostudies-arrayexpress

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