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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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CRISPR Cas9 screens for drug resistance in AML cell lines

ABSTRACT: Acute myeloid leukaemia (AML) continues to have a very high mortality and its treatment hasnot changed for more than 20 years.Here, we propose to apply genomic-wide screens to directly identify therapeutic vulnerabilitiesof AML using AML cells lines with pre-defined somatic mutations. Our studies will be basedon genome-wide CRISPR/CAs9 gRNA screens and will be used to identify drivers of drugresistance to standard chemotherapies.This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

INSTRUMENT(S): Illumina HiSeq 2500

ORGANISM(S): Human

SUBMITTER:

PROVIDER: E-ERAD-335 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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