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Metabolomics,Unknown,Transcriptomics,Genomics,Proteomics

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Comparative RNA seq analysis of three bacterial species

ABSTRACT: http://www.sanger.ac.uk/resources/downloads/bacteria/This data is part of a pre-publication release. For information on the proper use of pre-publication data shared by the Wellcome Trust Sanger Institute (including details of any publication moratoria), please see http://www.sanger.ac.uk/datasharing/

INSTRUMENT(S): Illumina HiSeq 2000

ORGANISM(S): Clostridium difficile

SUBMITTER:

PROVIDER: E-ERAD-97 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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The agr locus regulates virulence and colonization genes in Clostridium difficile 027.

Martin Melissa J MJ Clare Simon S Goulding David D Faulds-Pain Alexandra A Barquist Lars L Browne Hilary P HP Pettit Laura L Dougan Gordon G Lawley Trevor D TD Wren Brendan W BW

Journal of bacteriology 20130614 16

The transcriptional regulator AgrA, a member of the LytTR family of proteins, plays a key role in controlling gene expression in some Gram-positive pathogens, including Staphylococcus aureus and Enterococcus faecalis. AgrA is encoded by the agrACDB global regulatory locus, and orthologues are found within the genome of most Clostridium difficile isolates, including the epidemic lineage 027/BI/NAP1. Comparative RNA sequencing of the wild type and otherwise isogenic agrA null mutant derivatives of ...[more]

PMID: 23772065

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