Ontology highlight
ABSTRACT:
ORGANISM(S): Drosophila melanogaster
SUBMITTER: Eric Hoopfer
PROVIDER: E-GEOD-10013 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Hoopfer Eric D ED Penton Andrea A Watts Ryan J RJ Luo Liqun L
The Journal of neuroscience : the official journal of the Society for Neuroscience 20080601 24
Drosophila mushroom body (MB) gamma neurons undergo axon pruning during metamorphosis through a process of localized degeneration of specific axon branches. Developmental axon degeneration is initiated by the steroid hormone ecdysone, acting through a nuclear receptor complex composed of USP (ultraspiracle) and EcRB1 (ecdysone receptor B1) to regulate gene expression in MB gamma neurons. To identify ecdysone-dependent gene expression changes in MB gamma neurons at the onset of axon pruning, we u ...[more]