Effect of an AhR-/- on transcription in CD4 T cells from the spleen.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Markus Frericks
PROVIDER: E-GEOD-10084 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Transcriptional signatures of immune cells in aryl hydrocarbon receptor (AHR)-proficient and AHR-deficient mice.
Frericks Markus M Temchura Vladimir V VV Majora Marc M Stutte Susanne S Esser Charlotte C
Biological chemistry 20060901 9
The ligand-activated aryl hydrocarbon receptor (AHR) is known to modulate many genes in a highly cell-specific manner, either directly or indirectly via secondary effects. In contrast, little is known about the effects of AHR deficiency on gene expression balance. We compared the transcriptome of CD4 T cells from AHR-/- mice and wild-type mice; 390 genes, many of them immunotypic, were deregulated in AHR-deficient CD4 cells. TCDD-induced transcriptome changes correlated with the AHR expression l ...[more]
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