Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Mark Bieda
PROVIDER: E-GEOD-10090 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Johnson David S DS Li Wei W Gordon D Benjamin DB Bhattacharjee Arindam A Curry Bo B Ghosh Jayati J Brizuela Leonardo L Carroll Jason S JS Brown Myles M Flicek Paul P Koch Christoph M CM Dunham Ian I Bieda Mark M Xu Xiaoqin X Farnham Peggy J PJ Kapranov Philipp P Nix David A DA Gingeras Thomas R TR Zhang Xinmin X Holster Heather H Jiang Nan N Green Roland D RD Song Jun S JS McCuine Scott A SA Anton Elizabeth E Nguyen Loan L Trinklein Nathan D ND Ye Zhen Z Ching Keith K Hawkins David D Ren Bing B Scacheri Peter C PC Rozowsky Joel J Karpikov Alexander A Euskirchen Ghia G Weissman Sherman S Gerstein Mark M Snyder Michael M Yang Annie A Moqtaderi Zarmik Z Hirsch Heather H Shulha Hennady P HP Fu Yutao Y Weng Zhiping Z Struhl Kevin K Myers Richard M RM Lieb Jason D JD Liu X Shirley XS
Genome research 20080207 3
The most widely used method for detecting genome-wide protein-DNA interactions is chromatin immunoprecipitation on tiling microarrays, commonly known as ChIP-chip. Here, we conducted the first objective analysis of tiling array platforms, amplification procedures, and signal detection algorithms in a simulated ChIP-chip experiment. Mixtures of human genomic DNA and "spike-ins" comprised of nearly 100 human sequences at various concentrations were hybridized to four tiling array platforms by eigh ...[more]