Mapping translocation breakpoints by next-generation sequencing
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Reinhard Ullmann
PROVIDER: E-GEOD-10115 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Mapping translocation breakpoints by next-generation sequencing.
Chen Wei W Kalscheuer Vera V Tzschach Andreas A Menzel Corinna C Ullmann Reinhard R Schulz Marcel Holger MH Erdogan Fikret F Li Na N Kijas Zofia Z Arkesteijn Ger G Pajares Isidora Lopez IL Goetz-Sothmann Margret M Heinrich Uwe U Rost Imma I Dufke Andreas A Grasshoff Ute U Glaeser Birgitta B Vingron Martin M Ropers H Hilger HH
Genome research 20080307 7
Balanced chromosome rearrangements (BCRs) can cause genetic diseases by disrupting or inactivating specific genes, and the characterization of breakpoints in disease-associated BCRs has been instrumental in the molecular elucidation of a wide variety of genetic disorders. However, mapping chromosome breakpoints using traditional methods, such as in situ hybridization with fluorescent dye-labeled bacterial artificial chromosome clones (BAC-FISH), is rather laborious and time-consuming. In additio ...[more]
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