Unknown,Transcriptomics,Genomics,Proteomics

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Cells silenced for SDHB expression and tumor phenotype


ABSTRACT: Effect of SDHB silencing using siRNA methodologies in the tumor phenotype; We used microarrays to detail the global programme of gene expression when SDHB is silenced. Experiment Overall Design: Human hepatocellular carcinoma cell line Hep3B was stably silenced with control or SDHB-specific siRNAs.

This experiment was re-loaded into ArrayExpress in November 2010 after manual curation.

ORGANISM(S): Homo sapiens

SUBMITTER: Manolo Mata 

PROVIDER: E-GEOD-10289 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Cells silenced for SDHB expression display characteristic features of the tumor phenotype.

Cervera Ana M AM   Apostolova Nadezda N   Crespo Francisco Luna FL   Mata Manuel M   McCreath Kenneth J KJ  

Cancer research 20080601 11


Recently, enzymes of the tricarboxylic acid (TCA) cycle have emerged as novel tumor suppressors. In particular, mutations in the nuclear-encoded subunits of succinate dehydrogenase (SDHB, SDHC, and SDHD) cause paragangliomas and pheochromocytomas. Although the mechanism(s) by which disruption of mitochondrial metabolism leads to neoplasia is largely unknown, increasing evidence points to an activation of pseudohypoxia. In this study, we have shown that silencing of SDHB using DNA-based small int  ...[more]

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