Ontology highlight
ABSTRACT:
ORGANISM(S): Escherichia coli
SUBMITTER: Jai Tree
PROVIDER: E-GEOD-10319 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Infection and immunity 20090727 10
Recent work has highlighted a number of compounds that target bacterial virulence by affecting gene regulation. In this work, we show that small-molecule inhibitors affect the expression of the type III secretion system (T3SS) of Escherichia coli O157:H7 in liquid culture and when this bacterium is attached to bovine epithelial cells. Inhibition of T3SS expression resulted in a reduction in the capacity of the bacteria to form attaching and effacing lesions. Our results show that there is marked ...[more]