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Transcription profiling timecourse of human K562 cell line exposure to hemin

ABSTRACT: K562 cells (duplicate cultures A & B) are treated with 50 micromolar hemin for 0, 6, 12, 24, 48, 72 hours followed by RNA extraction and gene expression profiling on Affymetrix human U133A arrays and analysis by MAS 5.0

ORGANISM(S): Homo sapiens

SUBMITTER: Sankar Addya 

PROVIDER: E-GEOD-1036 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Publications

Erythroid-induced commitment of K562 cells results in clusters of differentially expressed genes enriched for specific transcription regulatory elements.

Addya Sankar S   Keller Margaret A MA   Delgrosso Kathleen K   Ponte Christine M CM   Vadigepalli Rajanikanth R   Gonye Gregory E GE   Surrey Saul S  

Physiological genomics 20040713 1

Understanding regulation of fetal and embryonic hemoglobin expression is critical, since their expression decreases clinical severity in sickle cell disease and beta-thalassemia. K562 cells, a human erythroleukemia cell line, can differentiate along erythroid or megakaryocytic lineages and serve as a model for regulation of fetal/embryonic globin expression. We used microarray expression profiling to characterize transcriptomes from K562 cells treated for various times with hemin, an inducer of  ...[more]

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