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Unknown,Transcriptomics,Genomics,Proteomics

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Transcription profiling of mice

ABSTRACT: Noval and traditional signaling pathways involved in cervical ripening that were regulated by MPA were identified. Experiment Overall Design: MPA treatment on E15 pregnant cervix (n=6) vs Vehicle group (n=6)

ORGANISM(S): Mus musculus

SUBMITTER: Hua Xu

PROVIDER: E-GEOD-10392 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Preventing cervical ripening: the primary mechanism by which progestational agents prevent preterm birth?

Xu Hua H Gonzalez Juan M JM Ofori Ella E Elovitz Michal A MA

American journal of obstetrics and gynecology 20080301 3

<h4>Objective</h4>Recent clinical trials suggest that progestational agents may prevent preterm birth, specifically in women with short cervices. These studies sought to assess novel pathways by which progestational agents (PAs) may modify signal transduction pathways that are involved in cervical ripening.<h4>Study design</h4>A microarray analysis was performed on pregnant mouse cervix that was exposed to a MPA. Appropriate microarray and cluster analyses were performed. Target genes of interes ...[more]

PMID: 18313454

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