Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Cécile Charrière-Bertrand
PROVIDER: E-GEOD-10395 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Breast cancer research : BCR 20081203 6
<h4>Introduction</h4>Snail, a family of transcriptional repressors implicated in cell movement, has been correlated with tumour invasion. The Plasminogen Activation (PA) system, including urokinase plasminogen activator (uPA), its receptor and its inhibitor, plasminogen activator inhibitor type 1(PAI-1), also plays a key role in cancer invasion and metastasis, either through proteolytic degradation or by non-proteolytic modulation of cell adhesion and migration. Thus, Snail and the PA system are ...[more]