Ontology highlight
ABSTRACT:
ORGANISM(S): Helicobacter pylori
SUBMITTER: Nina Salama
PROVIDER: E-GEOD-3478 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Björkholm B B Lundin A A Sillén A A Guillemin K K Salama N N Rubio C C Gordon J I JI Falk P P Engstrand L L
Infection and immunity 20011201 12
Helicobacter pylori has a very plastic genome, reflecting its high rate of recombination and point mutation. This plasticity promotes divergence of the population by the development of subclones and presumably enhances adaptation to host niches. We have investigated the genotypic and phenotypic characteristics of two such subclones isolated from one patient as well as the genetic evolution of these isolates during experimental infection. Whole-genome genotyping of the isolates using DNA microarr ...[more]