Profiling of Human Adipose Tissue and Effect of Sibutramine on Gene Expression
Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Andrey Loboda
PROVIDER: E-GEOD-10545 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Diurnal variation of the human adipose transcriptome and the link to metabolic disease.
Loboda Andrey A Kraft Walter K WK Fine Bernard B Joseph Jeffrey J Nebozhyn Michael M Zhang Chunsheng C He Yudong Y Yang Xia X Wright Christopher C Morris Mark M Chalikonda Ira I Ferguson Mark M Emilsson Valur V Leonardson Amy A Lamb John J Dai Hongyue H Schadt Eric E Greenberg Howard E HE Lum Pek Yee PY
BMC medical genomics 20090209
<h4>Background</h4>Circadian (diurnal) rhythm is an integral part of the physiology of the body; specifically, sleep, feeding behavior and metabolism are tightly linked to the light-dark cycle dictated by earth's rotation.<h4>Methods</h4>The present study examines the effect of diurnal rhythm on gene expression in the subcutaneous adipose tissue of overweight to mildly obese, healthy individuals. In this well-controlled clinical study, adipose biopsies were taken in the morning, afternoon and ev ...[more]
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