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Transcription profiling of uterus from 129/SvImJ wildtype mice treated with progesterone

ABSTRACT: Female mice used were 129/SvImJ wildtype (Jackson Lab), 10-16 weeks; of age. 14 days after ovariectomy, mice were injected; subcutaneously with progesterone dissolved in sesame oil (Sigma;; 0.2mg/0.1mL/mouse), followed by sacrifice and removal of uterine; horns at various times after injection. 8 uterine horns from 4 mice were; pooled to form one sample. Total RNA preparation, cRNA labeling and; hybridization were performed according to recommendations by; Affymetrix.

ORGANISM(S): Mus musculus

SUBMITTER: Richard Maas

PROVIDER: E-GEOD-106 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus.

Yao Mylene W M MW Lim Hyunjung H Schust Daniel J DJ Choe Sung E SE Farago Anna A Ding Yueyun Y Michaud Sebastien S Church George M GM Maas Richard L RL

Molecular endocrinology (Baltimore, Md.) 20030109 4

Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterin ...[more]

PMID: 12554760

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