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Transcription profiling of mouse uterine horns from Hoxa-10+/+ and Hoxa-10-/- littermates

ABSTRACT: Female mice used were SvJ/129, 10-16 weeks of age; Hoxa-10+/+ and Hoxa-10-/- littermates were used in parallel experiments. 14 days after ovariectomy, mice were injected subcutaneously with progesterone dissolved in sesame oil (Sigma; 0.2mg/0.1mL/mouse), followed by sacrifice and removal of uterine horns at 6 hours after injection. 8 uterine horns from 4 mice were pooled to form one sample. Total RNA preparation, cRNA labeling and hybridization were performed according to recommendations by Affymetrix. The 6 samples were obtained and processed in two batches: (1: GSM3047 and GSM3041), and (2: GSM3048, GSM3049, GSM3042, and GSM3043).

ORGANISM(S): Mus musculus

SUBMITTER: Richard Maas

PROVIDER: E-GEOD-108 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus.

Yao Mylene W M MW Lim Hyunjung H Schust Daniel J DJ Choe Sung E SE Farago Anna A Ding Yueyun Y Michaud Sebastien S Church George M GM Maas Richard L RL

Molecular endocrinology (Baltimore, Md.) 20030109 4

Human infertility and recurrent pregnancy loss caused by implantation defects are poorly understood. Hoxa-10-deficient female mice have severe infertility and recurrent pregnancy loss due to defective uterine implantation. Gene expression profiling experiments reveal that Hoxa-10 is an important regulator of two critical events in implantation: stromal cell proliferation and local immunosuppression. At the time of implantation, Hoxa-10 mediates the progesterone-stimulated proliferation of uterin ...[more]

PMID: 12554760

Similar Datasets

Transcription profiling of uterine horns from Hoxa-10+/+ and Hoxa-10-/- SvJ/129 mice treated with or without progesterone to study the progesterone-mediated roles of Hoxa-10 in preimplantation uterus.

Project description:This SuperSeries is composed of the following subset Series:; GSE108: OVX/P4/6h/UTX 129 WT vs. Hoxa-10-/-; GSE109: OVX/oil/6h/UTX 129 WT vs. Hoxa-10-/- Experiment Overall Design: Refer to individual Series. Female mice used were SvJ/129, 10-16 weeks of age; Hoxa-10+/+ and Hoxa-10-/- littermates were used in parallel experiments. 14 days after ovariectomy, mice were injected subcutaneously with progesterone dissolved in sesame oil (Sigma; 0.2mg/0.1mL/mouse) or sesame oil (Sigma; 0.1mL/mouse), followed by sacrifice and removal of uterine horns at 6 hours after injection. 8 uterine horns from 4 mice were pooled to form one sample. Total RNA preparation, cRNA labeling and hybridization were performed according to recommendations by Affymetrix.

2007-11-14 | E-GEOD-6439 | biostudies-arrayexpress

OVX/P4/6h/UTX 129 WT vs. Hoxa-10-/-

Project description:Female mice used were SvJ/129, 10-16 weeks of age; Hoxa-10+/+ and Hoxa-10-/- littermates were used in parallel experiments. 14 days after ovariectomy, mice were injected subcutaneously with progesterone dissolved in sesame oil (Sigma; 0.2mg/0.1mL/mouse), followed by sacrifice and removal of uterine horns at 6 hours after injection. 8 uterine horns from 4 mice were pooled to form one sample. Total RNA preparation, cRNA labeling and hybridization were performed according to recommendations by Affymetrix. The 6 samples were obtained and processed in two batches: (1: GSM3047 and GSM3041), and (2: GSM3048, GSM3049, GSM3042, and GSM3043). Keywords: other

2002-12-10 | GSE108 | GEO

OVX/oil/6h/UTX 129 WT vs. Hoxa-10-/-

Project description:Female mice used were SvJ/129, 10-16 weeks of age; Hoxa-10+/+ and Hoxa-10-/- littermates were used in parallel experiments. 14 days after ovariectomy, mice were injected with sesame oil (Sigma; 0.1mL/mouse), followed by sacrifice and removal of uterine horns at 6 hours after injection. 8 uterine horns from 4 mice were pooled to form one sample. Total RNA preparation, cRNA labeling and hybridization were performed according to recommendations by Affymetrix. All 6 samples were collected and processed in parallel. Keywords: other

2002-12-10 | GSE109 | GEO

Transcription profiling of uterine horns from SvJ/129 mice treated with progesterone to study the progesterone-mediated roles of Hoxa-10 in preimplantation uterus.

Project description:This SuperSeries is composed of the following subset Series: GSE106: OVX/P4/UTX 129/SvImJ WT A; GSE107: OVX/P4/UTX 129/SvImJ WT B Experiment Overall Design: Refer to individual Series. Female mice used were 129/SvImJ wildtype (Jackson Lab), 10-16 weeks of age. 14 days after ovariectomy, mice were injected subcutaneously with progesterone dissolved in sesame oil (Sigma; 0.2mg/0.1mL/mouse), followed by sacrifice and removal of uterine horns at various times after injection. 8 uterine horns from 4 mice were pooled to form one sample. Total RNA preparation, cRNA labeling and hybridization were performed according to recommendations by Affymetrix.

2007-11-15 | E-GEOD-6440 | biostudies-arrayexpress

Transcription profiling of mouse uterus from OVX/oil/6h/UTX 129 WT vs. Hoxa-10-/- animals

Project description:Female mice used were SvJ/129, 10-16 weeks of age; Hoxa-10+/+ and Hoxa-10-/- littermates were used in parallel experiments. 14 days after ovariectomy, mice were injected with sesame oil; (Sigma; 0.1mL/mouse), followed by sacrifice and removal of uterine; horns at 6 hours after injection. 8 uterine horns from 4 mice were; pooled to form one sample. Total RNA preparation, cRNA labeling and; hybridization were performed according to recommendations by; Affymetrix. All 6 samples were collected and processed in parallel.

2008-06-11 | E-GEOD-109 | biostudies-arrayexpress

Transcription profiling of mouse uterine horns from OVX/P4/UTX 129/SvImJ WT B

Project description:Female mice used were 129/SvImJ wildtype (Jackson Lab), 10-16 weeks; of age. 14 days after ovariectomy, mice were injected; subcutaneously with progesterone dissolved in sesame oil (Sigma;; 0.2mg/0.1mL/mouse), followed by sacrifice and removal of uterine; horns at various times after injection. 8 uterine horns from 4 mice were; pooled to form one sample. Total RNA preparation, cRNA labeling and; hybridization were performed according to recommendations by; Affymetrix.

2008-06-11 | E-GEOD-107 | biostudies-arrayexpress

OVX/P4/UTX 129/SvImJ WT B

Project description:Female mice used were 129/SvImJ wildtype (Jackson Lab), 10-16 weeks of age. 14 days after ovariectomy, mice were injected subcutaneously with progesterone dissolved in sesame oil (Sigma; 0.2mg/0.1mL/mouse), followed by sacrifice and removal of uterine horns at various times after injection. 8 uterine horns from 4 mice were pooled to form one sample. Total RNA preparation, cRNA labeling and hybridization were performed according to recommendations by Affymetrix. Keywords: time-course

2002-12-10 | GSE107 | GEO

OVX/P4/UTX 129/SvImJ WT A

2002-12-10 | GSE106 | GEO

Transcription profiling of uterus from 129/SvImJ wildtype mice treated with progesterone

2008-06-11 | E-GEOD-106 | biostudies-arrayexpress

Do differences in the endometrial transcriptome between uterine horns ipsilateral and contralateral to the corpus luteum influence conceptus growth to Day 14 in cattle?

Project description:This study relates to embryo-maternal interaction. The aim was to compare the transcriptome and ability of the ipsilateral and contralateral uterine horns to support preimplantation conceptus survival and growth to Day 14. Although differences in gene expression exist between the endometrium of uterine horns ipsilateral and contralateral to the CL in cattle, they do not impact conceptus survival or length between Days 7 and 14.

2018-08-15 | GSE118507 | GEO

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