Ontology highlight
ABSTRACT:
ORGANISM(S): Homo sapiens
SUBMITTER: Maria Figueroa
PROVIDER: E-GEOD-10887 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Figueroa Maria E ME Reimers Mark M Thompson Reid F RF Ye Kenny K Li Yushan Y Selzer Rebecca R RR Fridriksson Jakob J Paietta Elisabeth E Wiernik Peter P Green Roland D RD Greally John M JM Melnick Ari A
PloS one 20080326 3
The molecular heterogeneity of acute leukemias and other tumors constitutes a major obstacle towards understanding disease pathogenesis and developing new targeted-therapies. Aberrant gene regulation is a hallmark of cancer and plays a central role in determining tumor phenotype. We predicted that integration of different genome-wide epigenetic regulatory marks along with gene expression levels would provide greater power in capturing biological differences between leukemia subtypes. Gene expres ...[more]