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Adipose tissue of gonadectomized mice injected with dihydrotestosterone

ABSTRACT: Comparison of retroperitoneal adipose tissue of intact male mice and gonadectomized C57BL6 male mice. Gonadectomized mice were untreated or injected with dihydrotestosterone (DHT) and sacrificed 3 or 24 hours after injection. Keywords: other

ORGANISM(S): Mus musculus

SUBMITTER: Carl Bolduc

PROVIDER: E-GEOD-1091 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress

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Effects of dihydrotestosterone on adipose tissue measured by serial analysis of gene expression.

Bolduc C C Larose M M Yoshioka M M Ye P P Belleau P P Labrie C C Morissette J J Raymond V V Labrie F F St-Amand J J

Journal of molecular endocrinology 20041001 2

Intra-abdominal fat accumulation is related to several diseases, especially diabetes and heart disease. Molecular mechanisms associated with this independent risk factor are not well established. Through the serial analysis of gene expression (SAGE) strategy, we have studied the transcriptomic effects of castration and dihydrotestosterone (DHT) in retroperitoneal adipose tissue of C57BL6 male mice. Approximately 50,000 SAGE tags were isolated in intact and gonadectomized mice, as well as 3 and 2 ...[more]

PMID: 15525599

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