Expression data from an involution time course in wild type and E2F3 +/- mice.
Ontology highlight
ABSTRACT:
ORGANISM(S): Mus musculus
SUBMITTER: Eran Andrechek
PROVIDER: E-GEOD-11066 | biostudies-arrayexpress |
REPOSITORIES: biostudies-arrayexpress
Publications
Patterns of cell signaling pathway activation that characterize mammary development.
Andrechek Eran R ER Mori Seiichi S Rempel Rachel E RE Chang Jeffrey T JT Nevins Joseph R JR
Development (Cambridge, England) 20080611 14
Previous work has detailed the histological and biochemical changes associated with mammary development and remodeling. We have now made use of gene expression profiling, and in particular of the previously described signatures of cell signaling pathway activation, to explore the events associated with mammary gland development. We find that there is elevated E2F-specific pathway activity prior to lactation and relatively low levels of other important signaling pathways, such as RAS, MYC and SRC ...[more]
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